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Related Cat Virus Gives Clues Into The Origin Of HIV

7 December 2009 292 views 2 Comments

Cat VirusU.S. researchers reported on Sunday that an HIV genetic stowaway that may have come from a related cat virus could help the AIDS virus transmit and replicate in people, Reuters reported.

Experts said the finding has implications for designing new drugs or a vaccine against the fatal and incurable virus.

They said it might also shed light on how other viruses, such as swine flu, spread from animals to people.

Additionally, the recent discoveries could help explain how an ancient virus came to cause the devastating 25-year-long pandemic of AIDS.

The previously unnoticed stretch of genetic material in the RNA sequence of the virus has finally been discovered, according to Dr. Robert Bambara of the University of Rochester Medical Center in New York and colleagues.

HIV is a so-called retrovirus — it uses RNA, instead of DNA, to function. The researchers reported in the journal Nature Structural and Molecular Biology that the newly found bit of genetic material closely mimics a stretch of human RNA.

Bambara said in a statement: “We not only found the gene, but also a plausible explanation for why it is still there after millions of generations: its presence makes HIV dramatically better at reproducing inside of our cells.”

“This suggests new ways to shut down with drugs the ability of the virus to mass produce copies of itself,” he added.

Most experts believe that HIV likely jumped to humans from a close relative called simian immunodeficiency virus or SIV, which infects chimpanzees.

The researchers wrote that feline immunodeficiency virus (FIV), which infects cats, is thought to be the virus from which SIV originated and therefore an ancestor of HIV.

So far, experts say HIV-related viruses have been identified in sheep, goats, horse, cattle and cats, but only the cat virus FIV seems to be a close relative of HIV and SIV.

The newly discovered gene looks very much like human tRNALys, which HIV needs to replicate itself. HIV is similar to other viruses in that it “lives” by infecting cells, hijacking their machinery and turning them into factories that make copies of the virus.

The team said that determination of the origin of the tRNA-like sequence should provide valuable clues about the ancestry of HIV.

Matthew Portnoy of the National Institute of General medical Sciences, one of the National Institutes of Health, said studying this genetic sequence more may help scientists understand how viruses jump from animals to humans.

Portnoy said the study has broader implications beyond HIV research, and may impact the response to the current H1N1 flu pandemic, where that virus has jumped multiple species and picked up several parts of its genome from each of the many species it has passed through.

“Understanding the mechanisms of these transfers enables researchers to better understand the evolution of viruses, and hopefully to better predict their ‘next move’ as they design vaccines and treatments,” Portnoy said.

The United Nations shows that HIV now infects an estimated 33.4 million people and has killed 25 million.

H1N1 swine flu is still spreading globally and has infected tens of millions.

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2 Comments »

  • Pseudo said:

    HIV is man made. AIDS first appeared in gay men in Manhattan in 1979 then in heterosexual Africans in 1982 and both different strains. Just google special cancer virus program or hepatitis B vaccine program for gay men or Alan Cantwell HIV origin. Scientists just do not want to admit that their tinkering caused a global epidemic. The HIV/AIDS conspiracy theory is plausible considering the Cold War human radiation experiments that they carried out on Americans without their consent. Google that too.

  • Caramoantour said:

    It is quite scary that there is still no cure for HIV/AIDS and the only way we can fight it is by prevention. How long would it take our scientists to develop a cure or vaccine for this disease?

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